论著
陆圣雄
2014, 14(9): 1111-1113.
目的探讨不同化疗方案治疗乳腺癌的近期效果。方法以海口市第三人民医院2011年1月~2012年12月收治的80例Ⅱ-Ⅲ期乳腺癌患者为研究对象, 按照随机数字法将患者分为A组和B组,A组以多西他赛+表阿霉素（TE）方案治疗,B组以多西他赛+表阿霉素+环磷酰胺（TEC）方案治疗,观察两组的近期疗效。结果A组总有效率为82.5%,B组总有效率为87.5%,两组总有效率比较差异无统计学意义（χ2=0,46, P>0.05）。A组中白细胞减少率和血小板减少率分别为50.0%和 10.0%,均明显低于B组中白细胞减少率和血小板减少率 (77.5%和30.0%),两组比较差异有统计学意义（χ2=7.14~7,25,P<0.05）;A组和B组中胃肠道反应、口腔黏膜反应和肝功能损害以及心脏毒性的发生率比较差异均无统计学意义（χ2=0.16~0.51,P>0.05）。结论采用TE和TEC化疗方案治疗乳腺癌的近期效果比较相似,但是TE方案在白细胞减少和血小板减少方面优于TEC化疗方案,值得临床推广应用。
Abstract：Objective To investigate the effect of different chemotherapies on breast cancer patients. Methods Eighty breast cancer cases at II and III stages in Haikou Municipal Third People’s Hospital from January 2011 to December 2012 were divided into Group A and Group B. Cases in Group A were treated with docetaxel race +epirubicin (TE) regimen, and those in Group B were treated with docetaxel+ epirubicin + cyclophosphamide (TEC) regimen. The short-term effect in both groups were observed. Results The total effective rate in Group A was 82.5% and that in Group B was 87.5 %, respectively, showed no statistically significant difference between the two groups (χ2=0,46, P>0.05）. The rates of leucopenia and thrombocytopenia in Group A were 50.0%和 10.0%,and that in Group B were (77.5%和30.0%), showing significant difference between the two groups（χ2=7.14~7,25,P<0.05）While no significant differences were noticed in incidence of gastrointestinal tract reaction, oral mycosis,liver lesions and cardiac toxicity between the two groups（χ2=0.16~0.51,P>0.05）. Conclusions The shor-term effect of TE and TEC chemotherapy regimens on breast cancer cases is similar, but TE chemotherapy regimen is superior to TEC chemotherapy regimen in leucopenia and thrombocytopenia worthy for clinical application.
